What is the generic name of Opsutan?
Generic name of Opsutan is Macitentan.
Who is the manufacturer of Opsutan?
Opsutan is manufactured and marketed by Cipla Ltd.
Is Opsutan approved by USA FDA?
Yes, Opsutan is approved by FDA. The product was approved in 2013.
What are the storage conditions of Opsutan?
Store at 20ºC to 25ºC. Excursions are permitted between 15°C and 30°C.
How Opsutan is supplied?
Opsutan is available in 10mg , 10 tablets in one strip .
How does Opsutan work?
Endothelin (ET)-1 and its receptors (ETA and ETB) mediate a variety of deleterious effects, such as vasoconstriction, fibrosis, proliferation, hypertrophy, and inflammation. In disease conditions such as PAH, the local ET system is upregulated and is involved in vascular hypertrophy and in organ damage. Macitentan is an endothelin receptor antagonist that inhibits the binding of ET-1 to both ETA and ETB receptors.
Macitentan displays high affinity and sustained occupancy of the ET receptors in human pulmonary arterial smooth muscle cells. One of the metabolites of macitentan is also pharmacologically active at the ET receptors and is estimated to be about 20% as potent as the parent drug in vitro. The clinical impact of dual endothelin blockage is unknown.
What is Opsutan used for?
Pulmonary Arterial Hypertension
Macitentan is an endothelin receptor antagonist (ERA) indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to reduce the risks of disease progression and hospitalization for PAH. Effectiveness was established in a long-term study in PAH patients with predominantly WHO Functional Class II-III symptoms treated for an average of 2 years. Patients had idiopathic and heritable PAH (57%), PAH caused by connective tissue disorders (31%), and PAH caused by congenital heart disease with repaired shunts (8%)
How many brands of Opsutan are available in India?
Opsutan is a branded generic medicine. There are no other generics available in India.
Is there any generic or bio similar available for Opsutan.
Biosimilars/ Generics of Opsutan is not available in India.
What is the price of Opsutan in India?
You can call or WhatsApp +91-9650877511 or send mail to firstname.lastname@example.org to know the price.
Is it safe to buy Opsutan in India from local distributor?
It is always better to check the credential of the person / distributor before confirming.
As per the legal guidelines, only patients can import the product after getting proper Documentation.