Buy Melphalan 50 mg/vial

  • Innovator Brand Name: Evomela
  • API: Melphalan Hydrochloride
  • Packaging: Single-use vial
  • Strength: 50 mg/vial

Melphalan for Injection is an alkylating drug used as a:

  • high-dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation in multiple myeloma (MM) patients. 
  • palliative treatment for multiple myeloma (MM) patients for whom oral therapy is not appropriate.

For Conditioning Treatment: The recommended dose of Melphalan injection is 100 mg/m2/day administered over 30 min by intravenous infusion for two consecutive days (Day -3 and Day -2) prior to autologous stem cell transplantation (ASCT, Day 0).

For Palliative Treatment: The recommended dose of Melphalan is 16 mg/m2 administered as a single intravenous infusion over 15 to 20 minutes at 2-week intervals for 4 doses, then, after adequate recovery from toxicity, at 4-week intervals.

The most common melphalan side effects are white blood cell count decreased, neutrophil count decreased, lymphocyte count decreased, platelet count decreased, nausea, diarrhea, fatigue, anemia, hypokalemia, and vomiting. 

  • Melphalan for injection may cause local tissue damage should extravasation occur, and consequently it should not be given by direct injection into a peripheral vein. It is recommended that melphalan injection be given by injecting slowly into a fast-running IV infusion via an injection port, or via a central venous line.
  • Melphalan 50 mg injection should be given in carefully adjusted dosage by or under the apt supervision of experienced health specialists who are familiar with the medicine’s actions and the probable complications of its use.
  • Bone marrow suppression is the most significant toxicity associated with melphalan for injection in most patients. Hematologic tests (platelet count, white blood cell count, hemoglobin, and differential) must be performed at the beginning of therapy and before each subsequent dose. 
  • Hypersensitivity reactions including anaphylaxis have emerged in approximately 2 percent of patients who received the intravenous formulation of melphalan. These reactions typically occur after multiple courses of treatment.
  • Secondary malignancies, including myeloproliferative syndrome, acute nonlymphocytic leukemia, and carcinoma, have been noted in patients with cancer treated with any alkylating agents (including melphalan).
  • Melphalan is a pregnancy category D agent and may be responsible for causing fetal harm if given to a pregnant woman. Women of childbearing age or potential should avoid becoming pregnant.
  • It is not specified whether the drug melphalan hydrochloride is excreted in human milk. Intravenous melphalan should not be given to nursing mothers. Use of live vaccines by immunocom-promised patients should be avoided.

Is Melphalan approved by the FDA?

The FDA first approved Melphalan on March 10, 2016 for the treatment of patients with multiple myeloma (MM). 

What class of drug is Melphalan?

Melphalan belongs to a class of drugs called alkylating agents.

How to store Melphalan?

Store Melphalan at 25°C (77°F). Temperature excursions are permitted between 15 to 30°C (59 to 86°F). It is light sensitive. Retain the original carton until use. 

What should one do if someone takes an overdose of Melphalan?

  • The major toxic effect because of Melphalan (Alkacel) overdose is bone marrow suppression.
  • Hematologic parameters need to be precisely followed for 3-6 weeks.
  • Use of autologous bone marrow or hematopoietic growth factors may shorten the time-span of pancytopenia.
  • General supportive measures together with appropriate blood transfusions and antibiotics must be instituted as deemed necessary.
  • Melphalan is not eliminated from plasma to any significant degree by hemoperfusion or hemodialysis. 
  • Patients are instructed/encouraged to report all the negative adverse reactions due to melphalan tablets or injection to their health specialist. 

Is the drug Melphalan available in India?

Melphalan is a (prescription drug, doctor-prescribed medication, or health care professional-prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription.

Melphalan can be made available through the network of authorized distributors in India. (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.)

 

Can You Send the Multiple Myeloma medicine Melphalan to Foreign Destinations?

Buy generic Melphalan online at the best/lowest price in India from a leading supplier. Indian Generic Medicines can assist in the delivery of this medicine; the doctor prescribed medication to the USA, UK, Canada, Australia, China, Saudi Arabia, Thailand, South Africa, Zambia, Pakistan, Qatar, Kuwait, Sweden, Hong kong, UAE, Philippines, Kazakhstan, Turkey, Singapore, Malaysia, Sri Lanka, Uzbekistan Afghanistan, Nepal, Japan, and many more countries.

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