Lenvatinib is a kinase inhibitor indicated for the treatment of patients with locally recurrent or metastatic , progressive, radioactive iodine refractory differentiated thyroid cancer.
What is the generic name of Lenvima?
Generic name of Lenvima is Lenvatinib
Who is the manufacturer of Lenvima?
Lenvima is manufactured by Eisai Pharma.
Is Lenvima approved by USA FDA?
Yes, Lenvima is approved by FDA. The product was approved in 2015.
What is the dosage of Lenvima?
Lenvima is available as 4mg & 10mg .
DTC: The recommended dosage is 24 mg orally once daily.
RCC: The recommended dosage is 18 mg orally once daily with everolimus 5 mg orally once daily.
What are the storage conditions of Lenvima?
The product should be Stored at 20° to 25°C (68° to 77°F). Excursions are permitted between 15°C to 30°C (59°F to 86°F)
How Lenvima is supplied?
Lenvima is supplied as 4mg and 10mg , 20 capsules in one pack.
How does Lenvima work?
Lenvatinib is a kinase inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib inhibits other kinases that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. Lenvatinib also exhibited antiproliferative activity in hepatocellular carcinoma cell lines dependent on activated FGFR signaling with a concurrent inhibition of FGF-receptor substrate 2α (FRS2α) phosphorylation. The combination of lenvatinib and everolimus showed increased antiangiogenic and antitumor activity as demonstrated by decreases in human endothelial cell proliferation, tube formation, and VEGF signaling in vitro, and by decreases in tumor volume in mouse xenograft models of human renal cell cancer that were greater than those with either drug alone.
What is Lenvima used for?
Differentiated Thyroid Cancer LENVIMA is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer (DTC).
Renal Cell Carcinoma LENVIMA is indicated in combination with everolimus for the treatment of patients with advanced renal cell carcinoma (RCC) following one prior anti-angiogenic therapy.
Hepatocellular Carcinoma LENVIMA is indicated for the first-line treatment of patients with unresectable hepatocellular carcinoma (HCC).
Is there any generic or bio similar available for Lenvima.
Lenvima is an innovator brand of Lenvatinib. There are no other generic options available for Lenvatinib.
What is the price of Lenvima in India?
You can call or WhatsApp +91-9650877511 or send mail to firstname.lastname@example.org to know the price.
Is it safe to buy Lenvima in India from local distributor?
It is always better to check the credential of the person / distributor before confirming.
As per the legal guidelines, only patients can import the product after getting proper Documentation.