Cetuximab 100mg single vial

Cetuximab 100mg single vial

 

 

Facts Of Cetuximab

  • Medicine Name: Cetuximab
  • Generic Name: Cetuximab
  • Available as (Form & Strength):100mg, single vial for injection

 

 

Indication

CETUXIMABis an epidermal growth factor receptor (EGFR) antagonist indicated for treatment of:

Head and Neck Cancer

  • Locally or regionally advanced squamous cell carcinoma of the head and neck in combination with radiation therapy.
  • Recurrent locoregional disease or metastatic squamous cell carcinoma of the head and neck in combination with platinumbased therapy with fluorouracil.
  • Recurrent or metastatic squamous cell carcinoma of the head and neck progressing after platinum-based therapy.

Colorectal Cancer K-Ras wild-type, EGFR-expressing, metastatic colorectal cancer as determined by an FDA-approved test

  • in combination with FOLFIRI for first-line treatment
  • in combination with irinotecan in patients who are refractory to irinotecan-based chemotherapy,
  • as a single agent in patients who have failed oxaliplatin- and irinotecan-based chemotherapy or who are intolerant to irinotecan.

 

 

DOSAGE

Recommended Dosage for Squamous Cell Carcinoma of the Head and Neck (SCCHN)

In combination with radiation therapy or platinum-based therapy and fluorouracil

  • The recommended initial dose is 400 mg/m2 administered one week prior to initiating a course of radiation therapy or on the first day of platinum-based therapy and fluorouracil as a 120-minute intravenous infusion.
  • The recommended subsequent dosage (all other infusions) is 250 mg/m2 weekly as a 60-minute infusion for the duration of radiation therapy (6–7 weeks) or until disease progression or unacceptable toxicity when administered in combination with platinum-based therapy and fluorouracil.
  • Complete ERBITUX administration 1 hour prior to radiation therapy or platinum-based therapy with fluorouracil.

Monotherapy

  • The recommended initial dose is 400 mg/m 2 administered as a 120-minute intravenous infusion.
  • The recommended subsequent dosage (all other infusions) is 250 mg/m2 weekly as a 60-minute infusion until disease progression or unacceptable toxicity.

Recommended Dosage for Colorectal Cancer (CRC)

Determine EGFR-expression status using FDA-approved tests prior to initiating treatment.

  • The recommended initial dose, either as monotherapy or in combination with irinotecan or FOLFIRI (irinotecan, fluorouracil, leucovorin), is 400 mg/m2 administered as a 120-minute intravenous infusion.
  • The recommended subsequent dosage, either as monotherapy or in combination with irinotecan or FOLFIRI, is 250 mg/m2 weekly as a 60-minute infusion until disease progression or unacceptable toxicity.
  • Complete ERBITUX administration 1 hour prior to irinotecan or FOLFIRI.

 

 

Mode of Action

Cetuximab binds specifically to the EGFR on both normal and tumor cells, and competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor-alpha. In vitro assays and in vivo animal studies have shown that binding of cetuximab to the EGFR blocks phosphorylation and activation of receptor associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production.

 

 

Side Effect

  • Blemishes on the skin or pimples
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • chills
  • congestion
  • cough or hoarseness
  • deep cracks, grooves, or lines in the skin
  • difficult or labored breathing
  • dizziness
  • facial swelling
  • fever
  • headache
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • pale skin
  • rapid weight gain
  • runny nose

 

 

Who is the manufacturer of Cetuximab?
Cetuximab is manufactured and marketed by Merck Limited.

 

 

Is Cetuximab approved by USA FDA?
Yes, Cetuximab is approved by FDA. The product was approved in 2014.

 

 

What are the storage conditions of Cetuximab?
The product should be Stored at 2° to 8°C. Cetuximab vials should be protected from light. Do not freeze or shake.

 

 

How Cetuximab is supplied?
Cetuximab is supplied as Single Vial for Injection of 100mg and 500mg as single vial for injection.

 

 

How does Cetuximab work?
The epidermal growth factor receptor (EGFR, HER1, c-ErbB-1) is a transmembrane glycoprotein that is a member of a subfamily of type I receptor tyrosine kinases including EGFR, HER2, HER3, and HER4. The EGFR is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Expression of EGFR is also detected in many human cancers including those of the head and neck, colon, and rectum. Cetuximab binds specifically to the EGFR on both normal and tumor cells, and competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor-alpha. In vitro assays and in vivo animal studies have shown that binding of cetuximab to the EGFR blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. Signal transduction through the EGFR results in activation of wild-type KRAS protein. However, in cells with activating KRAS somatic mutations, the mutant KRAS protein is continuously active and appears independent of EGFR regulation.

 

 

What is Cetuximab used for?
Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Cetuximab® is indicated in combination with radiation therapy for the initial treatment of locally or regionally advanced squamous cell carcinoma of the head and neck.

 

 

Coloractal Cancer
Cetuximab, as a single agent, is indicated for the treatment of epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer after failure of both irinotecan and oxaliplatin-based regimens.

 

 

How many brands of Cetuximab are available in India?
Cetuximab is an innovator medicine. There are no other brands available for Cetuximab.

 

 

Is there any generic or bio similar available for Cetuximab.
There are no generic or biosimilar available for Cetuximab.

 

 

What is the price of Cetuximab in India?
You can call or WhatsApp +91-8826990915 or send mail to query@indiangenericmedicines.com to know the price.

 

 

Other information about Cetuximab
Ans.The European Court of Justice has determined that Roche’s Cetuximab may be reimbursed for ARMD- despite Novartis and Bayer’s challenge.

 

 

Is it safe to buy Cetuximab in India from local distributor?
It is always better to check the credential of the person / distributor before confirming.
As per the legal guidelines, only patients can import the product after getting proper Documentation.

 

 

Delivery
Indian Generic Medicines is able to get any valid prescription dispensed in shortest possible time. All prescriptions are dispensed and checked by registered pharmacists.

 

 

Is Cetuximab (Cetuximab) available in India?
Cetuximab (Cetuximab) is a (prescription drug, doctor prescribed medication or health care professional prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription.

Cetuximab (Cetuximab) can be made available through the network of authorised distributors in India. (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore and Pune etc.)

 

 

Can You Send Cetuximab (Cetuximab) to Foreign Destination?
Buy generic Cetuximab (Cetuximab) online best/lowest price in India from leading supplier. Indian Generic Medicines can assist in the delivery of Cetuximab (Cetuximab), doctor prescribed medicine to USA, UK, Canada, Australia, China, Saudi Arabia, Thailand, South Africa, Zambia, Pakistan, Qatar, Kuwait, Sweden, Hong kong, UAE, Philippines, Kazakhstan, Turkey, Singapore, Malaysia, Sri Lanka, Uzbekistan Afghanistan, Nepal, Japan, and many more countries.

We validate authenticity of suppliers. Our approved suppliers assure supply of genuine medicine against valid documents.

The Order Will Be Confirmed Only After The Receipt Of:

  • Valid prescription of Doctor and
  • Import permit if applicable




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Cetuximab 100mg single vial availability in India

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