Canmab 440mg single vial for injection
Facts of Canmab®
- Medicine Name: Canmab®
- Generic Name: Traztuzumab
- Company Name: Biocon Pharma
- Available as (Form & Strength):440mg single vial for injection
Metastatic Breast Cancer (MBC)
Traztuzumab is indicated for the treatment of metastatic breast cancer patients who have human epidermal growth factor receptor 2 (HER2)-overexpressing tumours.
Early Breast Cancer (EBC)
Traztuzumab is indicated for the treatment of adult patients with HER2-positive early breast cancer.
Traztuzumab should only be used in MBC or EBC patients who have tumours with either overexpression of HER2, or HER2 gene amplification.
Metastatic Gastric Cancer (MGC)
Traztuzumab in combination with capecitabine or 5-fluorouracil and cisplatin is indicated for the treatment of adult patients with HER2-positive metastatic adenocarcinoma of the stomach or gastroesophageal junction who have not received prior anti-cancer treatment for their metastatic disease.
Traztuzumab should be used in only those MGC patients whose tumours overexpress HER2.
Adjuvant Treatment, Breast Cancer
During and following paclitaxel, docetaxel, or docetaxel/carboplatin:
- Initial dose of 4 mg/kg as an intravenous infusion over 90 minutes then at 2 mg/kg as an intravenous infusion over 30 minutes weekly during chemotherapy for the first 12 weeks (paclitaxel or docetaxel) or 18 weeks (docetaxel/carboplatin).
- One week following the last weekly dose of Traztuzumab, administer Traztuzumab at 6 mg/kg as an intravenous infusion over 30−90 minutes every three weeks.
Metastatic Treatment, Breast Cancer
Administer Traztuzumab, alone or in combination with paclitaxel, at an initial dose of 4 mg/kg as a 90-minute intravenous infusion followed by subsequent once weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease progression.
Metastatic Gastric Cancer
Administer Traztuzumab at an initial dose of 8 mg/kg as a 90-minute intravenous infusion followed by subsequent doses of 6 mg/kg as an intravenous infusion over 30–90 minutes every three weeks until disease progression.
Mode of Action
The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Traztuzumab has been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2. Traztuzumab is a mediator of antibody-dependent cellular cytotoxicity (ADCC). In vitro, Traztuzumab-mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- chest pain
- cracked lips
- decreased frequency or amount of urine
- difficult or labored breathing
What is the generic name of Canmab?
Generic name of Canmab is Traztuzumab
Who is the manufacturer of Canmab?
Canmab is manufactured and marketed by Biocon Pvt. Ltd.
Is Canmab approved by USA FDA?
Yes, Canmab is approved by FDA. The product was approved in 1998.
How Canmab is supplied?
Canmab is available in 150mg and 440mg, single vial for Injection.
What are the storage conditions of Canmab?
The product should be Stored at 2° to 8°C. Canmab vials should be protected from light. Do not freeze or shake.
How does Canmab work?
The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Canmab has been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2.
What is Canmab used for?
Adjuvant Breast Cancer
Canmab is indicated for adjuvant treatment of HER2 overexpressing node positive or node negative (ER/PR negative or with one high risk feature
- as part of a treatment regimen consisting of doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel
- as part of a treatment regimen with docetaxel and carboplatin
- as a single agent following multi-modality anthracycline based therapy
Metastatic Breast Cancer
Canmab is indicated:
- In combination with paclitaxel for first-line treatment of HER2-overexpressing metastatic breast cancer • As a single agent for treatment of HER2-overexpressing breast cancer in patients who have received one or more chemotherapy regimens for metastatic disease
Metastatic Gastric Cancer
Canmab is indicated, in combination with cisplatin and capecitabine or 5-fluorouracil, for the treatment of patients with HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma who have not received prior treatment for metastatic disease
How many brands of Canmab are available in India?
Canmab is an branded generic medicine. There are other biosimilars available in India.
Is there any generic or bio similar available for Canmab.
Biosimilars of Canmab are available in India.
What is the price of Canmab in India?
You can call or WhatsApp +91-8826990915 or send mail to firstname.lastname@example.org to know the price.
Is it safe to buy Canmab in India from local distributor?
It is always better to check the credential of the person / distributor before confirming.
As per the legal guidelines, only patients can import the product after getting proper Documentation.
Indian Generic Medicines is able to get any valid prescription dispensed in shortest possible time. All prescriptions are dispensed and checked by registered pharmacists.
Is Canmab (Bevacizumab) available in India?
Canmab (Bevacizumab) is a (prescription drug, doctor prescribed medication or health care professional prescribed medicine) pharmaceutical drug that can be legally dispensed against a medical prescription.
Canmab (Bevacizumab) can be made available through the network of authorised distributors in India. (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore and Pune etc.)
Can You Send Canmab (Bevacizumab) to Foreign Destination?
Buy generic Canmab (Bevacizumab) online best/lowest price in India from leading supplier. Indian Generic Medicines can assist in the delivery of Canmab (Bevacizumab), doctor prescribed medicine to USA, UK, Canada, Australia, China, Saudi Arabia, Thailand, South Africa, Zambia, Pakistan, Qatar, Kuwait, Sweden, Hong kong, UAE, Philippines, Kazakhstan, Turkey, Singapore, Malaysia, Sri Lanka, Uzbekistan Afghanistan, Nepal, Japan, and many more countries.
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The Order Will Be Confirmed Only After The Receipt Of:
- Valid prescription of Doctor and
- Import permit if applicable