What is the generic name of Atgam?
Generic name of Atgam is Anti-thymocyte globulin injection
Who is the manufacturer of Atgam?
Atgam is manufactured by Pharmacia and Upjohn and marketed by Pfizer Products Pvt. Ltd.
Is Atgam approved by USA FDA?
Yes, Atgam is approved by FDA. The product was approved in 1981
What is the dosage form of Atgam?
Atgam is available as 250mg, single vial for Injection (Pack of 5 vials)
What are the storage conditions of Atgam 250 mg?
The product should be stored at 2° to 8°C. Atgam vials should be protected from light. Do not freeze or shake.
How Atgam 250 mg is supplied?
Atgam is supplied as pack of 5 vials, each of 250mg strength.
How does Atgam 250mg work?
ATGAM is composed of antibodies that bind a wide variety of proteins on the surface of lymphocytes. In addition, ATGAM binds to granulocytes, platelets, bone marrow cells, and other cell types. The mechanism of ATGAM-induced immunosuppression has not been determined. Published data indicate that the primary mechanism is the depletion of circulating lymphocytes, with greatest effect on T lymphocytes. Lymphocyte depletion may be caused by complement dependent lysis and/or activation-induced apoptosis. In addition, immunosuppression may be mediated by the binding of antibodies to lymphocytes which results in partial activation and induction of T lymphocyte anergy.
The mechanism of ATGAM therapy for aplastic anemia is attributed to its immunosuppressive actions. In addition, ATGAM directly stimulates the growth of hematopoietic stem cells and release of hematopoietic growth factors such as interleukin-3 and granulocyte/macrophage colony stimulating factor.
What is Atgam 250mg used for?
Renal Allograft Rejection
Renal transplant rejection: ATGAM 250 mg is indicated for the management of allograft rejection in renal transplant patients; when administered with conventional therapy at the time of rejection ATGAM increases the frequency of resolution of the acute rejection episode.
ATGAM is indicated for the treatment of moderate to severe aplastic anemia in patients unsuitable for bone marrow transplantation.
The usefulness of ATGAM 250 mg has not been demonstrated in patients with aplastic anemia who are suitable candidates for bone marrow transplantation or in patients with aplastic anemia secondary to neoplastic disease, storage disease, myelofibrosis, Fanconi’s syndrome, or in patients known to have been exposed to myelotoxic agents or radiation
Is there any generic or bio similar available for Atgam 250mg.
There are no generic of Atgam.